紹介記事・論文

主要原著論文

302007-12-31

Harada H , Goto Y , Ohno T , Suzu S , Okada S . Proliferative activation up-regulates expression of CD4 and HIV-1 co-receptors on NK cells and induces their infection with HIV-1. Eur. J. Immunol., (2007), 37, 2184-2155.

292007-12-31
Ishikawa, Eiichi; Tsuboi, Koji; Yamamoto, Tetsuya; Muroi, Ai; Enomoto, Takao; Takano, Shingo; Matsumura, Akira; Ohno, Tadao: A clinical trial of autologous formalin-fixed tumor vaccine for glioblastoma multiforme patients. Cancer Sci., 98(8):1226-1233, 2007.
282005-07-30
Tsurushima H, Yoshii Y, Leong KW, Ohno T.: Targeted tumor cell death induced by autologous tumor-Specific T lymphocyte recognition of wild-type p53-derived peptides. J Neurooncol. 2005 Jul 30; [Epub ahead of print] .
272004-12-11
Kawai K, Saijo K, Oikawa T, Ohno T, Akaza H.: Enhancement of T cell proliferative response against autologous cancer cells of a metasatic renal cell carcinoma patient after unexplained regression. Int J Urol. Dec;11(12):1130-2, 2004.
262005-12-31

Ghosh, M., Koike, N., Tsunoda, S., Hirano, T., Kaul, S., Kashiwagi, H., Kawamoto, T., Ohkohchi, N., Saijo, K., Ohno, T., Miwa, M., and Todoroki, T.: Characterization and genetic analysis in the newly established human bile duct cancer cell lines. Int. J. Oncol. 26:449-456, 2005.

252004-12-31

Ishikawa, E., Tsuboi, K., Saijo, K.,Harada, H., Takano, S., Nose, T., Ohno, T.: Autologous Natural Killer Cell Therapy for Human Recurrent Malignat Glioma. Anticancer Research. 24: 1861-1872, 2004.

242004-12-31

Ishikawa, E., Tsuboi, K., Saijo, K., Takano, S., and Ohno, T.: X-irradiation to human malignant glioma cells enhances the cytotoxicity of autologous killer lymphocytes under specific conditions. Int. J. Radiation Oncology Biol. Phys. 59: 1505-1512, 2004.

232004-12-31

Harada, H., Watanabe, S., Saijo, K., Ishiwata, I., and Ohno, T.: A Wilms tumor cell line, HFWT, can greatly stimulate proliferation of CD56+ human natural killer cells and their novel precursors in blood mononuclear cells. Exp. Hematol. 32: 614-621, 2004.

222004-12-31

Harada, H., Saijo, K., Ishiwata, I., and Ohno, T.: A GFP-transfected HFWT cell line, GHINK-1, as a novel target for non-RI activated natural killer cytotoxicity assay. Human Cell, 17: 43-48, 2004.

212004-12-31

Kushida, S., Peng, B. G., Uchimura, E., Kuang, M., Huang, L., Miwa, M., and Ohno, T.: A tumor vaccine of fixed tumor fragments in a controlled-release vehicle with cytokines for therapy of hepatoma in mice. Digestive and Liver Disease, 36: 478-485, 2004.

202004-03-12

Ming Kuang, Bao G. Peng, Ming D. Lu, Li J. Liang, Jie F. Huang, Qiang He, Yun P. Hua, Saeri Totsuka, Shu Q. Liu, Kam W. Leong and Tadao Ohno*: Phase II Randomized Trial of Autologous Formalin-Fixed Tumor Vaccine for Postsurgical Recurrence of Hepatocellular Carcinoma. Clin. Cancer Res. 10: 1574-1579, 2004.

192004-12-31

Mila Ghosh, Naoto Koike, Go Yanagimoto, Shin-ichi Tsunoda, Sunil Kaul, Takashi Hirano, Fabian Emura, Hironobu Kashiwagi, Toru Kawamoto, Nobuhiro Ohkohchi, Kaoru Saijo, Tadao Ohno, Masanao Miwa, and Takeshi Todoroki*: Establishment and characterization of unique human gallbladder cancer cell lines. Int'l. J. Oncol. 24: 1189-1196, 2004.

182004-12-31

Eiichi Ishikawa , Koji Tsuboi , Shingo Takano , Eiji Uchimura , Tadao Nose, and Tadao Ohno*: Intratumoral injection of IL-2-activated NK cells enhances the antitumor effect of an intradermally injected paraformaldehyde-fixed tumor vaccine in a rat intracranial brain tumor model. Cancer Sci. 95: 98-103, 2004.

172003-12-31

Fabian Emura, Hiroshi Kamma, Mila Ghosh, Naoto Koike, Toru Kawamoto, Kaoru Saijo, Tadao Ohno, Nobuhiro Ohkohchi, and Takeshi Todoroki*: Establishment and characterization of novel xenograft models of human biliary tract carcinomas. Int'l. J. Oncol. 23: 1293-1300, 2003.

162003-12-31

Koji Tsuboi*, Kaoru Saijo, Eiichi Ishikawa, Hideo Tsurushima, Shingo Takano, Yukio Morishita and Tadao Ohno: Effects of Local Injection of ex Vivo Expanded Autologous Tumor-specific T Lymphocytes in Cases with Recurrent Malignant Gliomas. Clinical Cancer Research, 9: 3294-3302, 2003.

152002-12-31

Peng, B. G., Liu, S. Q., Kuang, M., He, Q., Totsuka, S., Huang, L., Huang, J., Lu, M-D., Liang, L-J., Leong, K. W., and Ohno, T.*: Autologous fixed tumor vaccine: A formulation with cytokine-microparticles for protective immunity against recurrence of human hepatocellular carcinoma. Jpn. J. Cancer Res. 93: 363-8, 2002.

142002-12-31

Harada, H., Saijo, K., Watanabe, S., Tsuboi, K., Nose, T., Ishiwata, I., Ohno, T.*: Selective expansion of human natural killer cells from peripheral blood mononuclear cells by the cell line, HFWT. Jpn. J. Cancer Res. 93: 313-9, 2002.

132001-12-31

Masters, J. R.*, Thomson, J. A., Daly-Burns, B., Reid, Y. A., Dirks, W. G., Packer, P., Toji, L. H., Ohno, T., Tanabe, H., Arlett, C. F., Kelland, L. R., Harrison, M., Virmani, A., Ward, T. H., Ayres, K. L., Debenham, P. G.: Short tandem repeat profiling provides an international reference standard for human cell lines. Proc. Natl. Acad. Sci., U S A. 98: 8012-7, 2001.

122000-12-31

Kim, C. H., Todoroki, T., Matsumura, M., and Ohno, T.*: Eligibility of antigenic-peptide pre-loaded and fixed adhesive peripheral blood cells for induction of cytotoxic T lymphocytes for cancer patients with elevated serum CEA levels. J. Cancer Res. Clin. Oncol., 126: 383-390, 2000.

111999-12-31

Tsurushima, H., Liu, S. Q., Tuboi, K., Matsumura, A., Yoshii, Y., Nose, T., Saijo, K. and Ohno, T.*: Reduction of end-stage malignant glioma by injection with autologous cytotoxic T lymphocytes. Jpn. J. Cancer Res.., 9, 536-545, 1999.

101999-12-31

Saijo, Y.*, Hong, X., Tanaka, M., Tazawa, R., Liu, S. Q., Saijo, K., Ohno, T., Koike, K., Ohkuda, K., Saitoh, K., and Nukiwa, T.: Autologous high-killing cytotoxic T lymphocytes against human lung cancer are induced using interleukin (IL)-1b, IL-2, IL-4, and IL-6: Possible involvement of dendritic cells. Clinical Cancer Research, 5, 1203-1209, 1999.

091998-12-31

Liu, S. Q., Kawai, K., Shiraiwa, H., Hayashi, H. Akaza, H., Hashizaki, K., Shiba, R., Saijo, K., Ohno, T.*: High rate of induction of human autologous cytotoxic T lymphocytes against renal carcinoma cells cultured with an interleukin cocktail. Jpn. J. Cancer Res., 89: 1195-1201, 1998.

081998-12-31

Kohyama, M., Saijo, K., Hayashida, M., Yasugi, T., Kurimoto, M., and Ohno, T.*: Direct activation of human CD8+ cytotoxic T lymphocytes by interelukin-18. Jpn. J. Cancer Res., 89: 1041-1046, 1998.

071998-12-31

Kim, C., Matsumura, M., Saijo, K., Ohno, T.*: In vitro induction of HLA-A2402-restricted and carcinoembryonic-antigen-specific cytotoxic T lymphocytes on fixed autologous peripheral blood cells. Cancer Immunol. Immunother., 47: 90-96, 1998.

061997-12-31

Horiuchi, K., Tsurushima, H., Kim, B. S., Liu, S. Q., Saijo, K., Saijo, Y., Nukiwa, T., Nomura, N., Matsumura, M., Ohno, T.*: Expansion of human autologous cytotoxic T lymphocytes on fixed target tumor cells. Cytotechnology, 26, 119-124, 1997.

051996-12-31

Tsurushima, H., Liu, S. Q., Tsuboi, K., Yoshii, Y., Nose, T. and Ohno, T.*: Induction of human autologous cytotoxic T lymphocytes on minced tissues of the brain tumor, glioblastoma multiforme. J. Neurosurgery, 84, 258-263, 1996.

041996-12-31

Liu, S. Q., Shiraiwa, H., Kawai, K., Hayashi, H., Akaza, H., Kim, B. S., Oki, A., Nishida, M., Kubo, T., Hashizaki, K., Saijo, K. and Ohno, T.*: Tumor-specific autologous cytotoxic T lymphocytes from tissue sections. Nature Medicine, 2: 1283-1283, 1996.

031995-12-31

Liu, S. Q., Saijo, K., Todoroki, T., and Ohno, T.* : Induction of human autologous cytotoxic T lymphocytes on formalin-fixed and paraffin-embedded tumour sections. Nature Medicine, 1, 267-271, 1995.

021994-12-31

Liu, S. Q., Shiba, R. Kim, B. S., Saijo, K. and Ohno, T.* : Long-term serum/plasma-free culture of human cytotoxic T lymphocytes induced from peripheral blood mononuclear cells. Cancer Immunol. Immunother., 39, 279-285, 1994.

011992-12-31

Kawai, K., Sasaki, T., Saijo-Kurita, K., Akaza, H., Koiso, K., and Ohno, T.*: Additive effects of antitumor drugs and lymphokine-activated killer cell cytotoxic activity in tumor cell killing determined by lactate-dehydrogenase assay. Cancer Immunol. Immunother., 35:225-229, 1992.