・Session Category: Clinical Research
・Session Title: Adoptive Cell Therapy, Immune Checkpoints, and Vaccines
・Session Date and Time: Monday Apr 18, 2016 1:00 PM-5:00 PM
・Location: Convention Center, Halls G-J, Poster Section21
Long lasting CR status of stage IV gall bladder cancer and colon cancer after combined treatment including autologous formalin-fixed tumor vaccine (AFTV)
Fumito Kuranishi 1), Yusuke Sumi 1), Ogawa Yoshiteru 1), Yoji Uemae 2), Tadao Ohno 2)
1) Innoshima Ishikai Hospital, Dep. Surgery, Innoshima, Hiroshima, Japan
2) Cell-Medicine Inc., Tsukuba, Ibaraki, Japan
(INTRODUCTION) The prognosis of advanced (stage IV) cancer is very poor. However, we have already reported two cases of eradication of advanced breast cancer with bone metastasis (AACR 2013 and AACR 2015) after combined treatments including AFTV. We here additionally report successful cases of gall bladder cancer (stage IV, liver metastasis) and colon cancer (stage IV, lung metastasis).
(CASE 1) A 61-year-old female with stage IV gall bladder cancer (T3N1M1: liver metastasis) was operated in May 2011 including partial resection of liver. She was treated with, as the first-line adjuvant therapy, AFTV followed with conventional chemotherapy. This patient is still alive without any recurrence confirmed by CT etc.
(CASE 2) A 67-year-old male with stage IV (N3, H0, P1, M1: lung, lt. adrenal gland, abdominal wall) was operated in August 2009. Then conventional chemotherapy, 2 courses of AFTV and radiation were applied sequentially. No recurrence was observed for more than 5 years.
(DISCUSSION) We diagnosed both patients staying at long lasting complete remission. The prognoses of stage IV gall bladder cancer and abdominal wall-metastasized colon cancer are very poor despite of conventional treatments. Adverse effects of AFTV were less than grade 2, therefore combination therapies including AFTV are worth to consider, although larger scale clinical trial is essential.