A transient increase and subsequent sharp decrease of chemo-refractory liver-metastasized uterine cervical small cell carcinoma to autologous formalin-ﬁxed tumor vaccine plus anti-PD-1 antibody
Clinical Case Reports 2016; 4(7): 687–691.
1, 1, 1, 1, 1, 2, & 2
1. Ginza-Namiki-Dori Clinic, Ginza 4-2-2 First Yayoi Bldg 7F, Chuo-ku, Tokyo 104-0061, Japan
2. Cell-Medicine, Inc., Sengen 2-1-6, Tsukuba Science City, Ibaraki 305-0047, Japan
Key Clinical Message:
Uterine cervical small cell carcinoma is rare and aggressive with no standardized therapy. A patient bearing the advanced chemo-refractory carcinoma, treated with a tumor vaccine combined with 1 mg/kg of pembrolizumab, showed a transient increase and subsequent sharp decrease of the liver-metastasized lesion to less than half its maximum diameter.